Effect of Triphosphate Nucleosides of 8-Azaguanine, 6-Thioguanine, and 6-Mercaptopurine on Amino Acid Incorporation in Vitro into Microsomal Protein
نویسندگان
چکیده
منابع مشابه
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep. 2 cells grown in culture. Toxicity is not reversed by aminoimidazolecarboxamide, suggesting that inhibition of purine biosynthesis de novo is not the sole mechanism of toxicity. Also, 6-(methylmercapto)purine ribonucleoside, a potent inhibitor of purine biosynthesis de novo, produces more marked r...
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هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...
The effect of 6-mercaptopurine on the incorporation of labeled amino acids into cellular protein of chronic granulocytic leukemia leukocytes.
F RANTZ afl(l Zamecnik’ I)oiIlLe(l out that in vitro incorporation of C’4-leucine and C’4-alanine into white cell proteins was about six times greater in acute leukemic cells, as compared with normal leukecytes. Similar findings were obtained by \Veisberger et ;il23 using S35LcyTstii e and S 5-L-methionine. Baker, Zaniecnik and Stephenson4 showed that cells from cases of chronic’ Invelogenous l...
متن کاملThe effects of 8-azaguanine and 6-mercaptopurine on purine catabolism in the rat.
Various purine analogs active as carcinostatic agents have previously been shown to act as po tent inhibitors of xanthine oxidase in vitro in both homogenate and isolated enzyme systems (4, 5). 8-Azaguanine (8-AG) has been demonstrated to be an in vitro inhibitor of both xanthine oxidase and uricase (4, 9). Elion et al. have reported that 6mercaptopurine (6-MP) is a substrate for xanthine oxida...
متن کاملthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1961
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64259-0